THE EFFECT OF VITAMIN C ON PHARMACOKINETIC PARAMETERS OF CHLOROQUINE IN HEALTHY HUMAN VOLUNTEERS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
This study was undertaken to compare the effect of vitamin C on the pharmacokinetics of chloroquine using human volunteers. Quality control studies for both chloroquine and vitamin C; identification test, assay, weight variation, friability, disintegration time and dissolution rate were carried out according to BP 2009. Jayanathi et al., 1994 method was adopted and validated based on ICH guideline for this study. Calibration curve was constructed within the range of 2 – 10 µg/ml and validated. The adopted method was then employed in determining the effect of vitamin C on the pharmacokinetics parameters (Cmax, Tmax, Ka, Ke, t1/2a, t1/2e, Cl, Vd, lag time and AUC) of chloroquine using human volunteers of 30 years and above and the study was divided into three phases with a washout period of three weeks. Both chloroquine and vitamin C used for this study were found to have the labeled active ingredient. They all passed the assay test as they were within the acceptable limits 95 – 105 %. Weight variation was conducted for both chloroquine and vitamin C and they all passed as their percentage mean deviation was less than 5 %. Similarly, both drugs passed the friability test which was less than 1%. Disintegration tests for both drugs reveals that they disintegrate in less 5 mins and also both chloroquine and vitamin C passed the dissolution rate as more than 70 % of the active ingredient was released in 30 mins. The percentage recovery of the method was within the accepted range of 98 – 102 %. Calibration curve was linear within the range of 2 – 10 µg/ml as the correlation coefficient was 0.9905. The regression equation was y= 0.001x + 0.120. When chloroquine was administered alone no significant difference (p<0.05) at lower values was observed, however, on coadministration of chloroquine and vitamin C no significant difference (p<0.05) at lower values was also observed, except for clearance (Cl) which was statistically significant vii (p<0.05) at lower values. On the other hand, when an hour delayed administration of chloroquine and vitamin C no significant difference (p<0.05) was observed, except for clearance (Cl) which was also statistically significant (p<0.05) at lower values. This finding indicates that vitamin C may influence the pharmacokinetics of chloroquine when coadministered together depending on the time of administration of the two drugs.
Related Project Materials
CASHLESS POLICY AND ITS IMPACT ON ECONOMIC GROWTH OF NIGERIA
Background Of The Study
The introduction of electronic banking, online transactions and mobile banking...
ISOLATION IDENTIFICATION AND CHARATERIZATION OF FUNGI ASSOCIATED WITH THE SPOILAGE OF CORN
ABSTRACT
Fungi spoilage organisms are silently invading acidifying, fermenting, discoloring, and disintegrating microbes...
AN ASSESSMENT OF THE ADVANCES IN SEARCH ENGINE TECHNOLOGY AND THEIR IMPACTS ON LIBRARIES
Background of study
Some individuals see physical libraries as antiquated relics of a bygone era, given...
EFFECTS OF SOCIAL NETWORKING ON THE ACADEMIC ACHIEVEMENT OF SENIOR SECONDARY SCHOOL STUDENTS
ABSTRACT
The study investigated the effect of social networking on academic achievement of senior secondary school students in Abeokuta,...
EFFECTIVENESS OF PHOTOGRAPHY AS A TEACHING METHOD FOR SCIENCE SUBJECTS IN SECONDARY SCHOOLS IN NIGERIA
ABSTRACT
In spite of the fact that most teachers of science have been trained in the u...
BUSINESS EDUCATION STUDENTS ENTREPRENEURSHIP SKILLS ACQUISITION IN DIGITAL ERA FOR SELF-EMPLOYMENT IN UNIVERSITIES IN RIVERS STATE
BACKGROUND OF THE STUDY
According to the Australian Government (2015), the contemporary education...
EFFECT OF COLLABORATIVE TEACHING METHOD ON ACADEMIC ACHIEVEMENT OF SECONDARY SCHOOL STUDENTS IN FINANCIAL ACCOUNTING IN OYO STATE, NIGERIA
Background to the Study
Education is a vehicle which conveys people from unknown to known or from abstract to concrete...
THE EFFECT OF DEBT FINANCING ON FINANCIAL PERFORMANCE OF MANUFACTURING FIRMS IN WESTERN NIGERIA
Debt Financing
Borrowing of lo...
POVERTY ALLEVIATION ON PLANTAIN AND BANANA FARMERS
ABSTRACT
The study focused on poverty alleviation among plantain and banana farmers in Ovia South North East Local Government Area of...
COMPARATIVE ANALYSIS OF EDUCATION/ECONOMICS AND ECONOMICS STUDENTS PATTERN OF CARRYOVER
Abstract
Education is the best legacy a nation can give to her citizens especially the youth. This is because the devel...
